219 RESULTS
COMMENT This is an important paper which describes the temporal relationship between changes in CSF Aβ42 and in PIB-PET signals. The work implies that the latter changes precede the former. This observation is probably consistent with the presumption that Aβ plaq
COMMENT This work strongly suggests that the molecular mechanism(s) downstream of Aβ deposition need to be identified to fully understand the pathophysiology of AD. Aβ alone is not enough. 0 saido
COMMENT A unique viewpoint! 0 saido
COMMENT Important to note. 0 saido
COMMENT Interesting! 0 saido
COMMENT Solid work. This may lead to elucidation of mechanism(s) for tauopathy. 0 saido
COMMENT This work is consistent with the observation that amyloid deposition starts about 25 years before the disease onset. 0 saido
COMMENT This is a very important work demonstrating the potential relationship between Pin1 and tauopathy. 0 saido
COMMENT Interesting! 0 saido
COMMENT What happens to calpastatin, calpain-specific inhibitor protein? 0 saido
COMMENT This is an interesting paper that implies that synucleinopathy in CNS may be transmitted to enteric neurons. 0 saido
COMMENT Good to know. 0 saido
COMMENT We need a selective PET ligand for tauopathy. 0 saido
COMMENT This is one important step. 0 saido
COMMENT This could be an important finding. 0 saido
