Jobs
Postdoctoral Fellow Position to Study TDP-43 Proteinopathy in Alzheimer’s Disease and Related Disorders
Posted 06 Dec 2023
Employer
University of Kentucky/ Sanders-Brown Center on Aging
Location
Lexington, Kentucky
Principal Investigator
Contact
Description
Selenica’s laboratory is currently looking for highly skilled and motivated molecular and cell biologists to be the drivers of efforts to unravel mechanisms contributing to the TDP-43 pathology of limbic-predominant age-related TDP-43 encephalopathy (LATE) and Alzheimer’s Disease Related Dementias (ADRD). Core areas of focus will be understanding the role of novel PTMs in TDP-43 protein structure, biology, and pathology both in vitro (induced pluripotent stem cell models) and in vivo systems (mouse models). Our lab focuses on the molecular, cellular, and tissue-level mechanisms by which these various PTMs and the associated enzymes modulate disease risk. The candidate will join a multidisciplinary and highly collaborative research team that includes geneticists, immunologists, biostatisticians, neuroscientists, and neuropathologist at the Sanders-Brown Center on Aging as one of the leading centers in the country for ADRD and LATE research and clinical interventions.
Requirements
- Ph.D. in biology, neuroscience, or related field with deep expertise in molecular and cellular biology techniques.
- Strong research experience in human iPSC technology and targeted genome editing in vitro (preferred) – or – in high-throughput technologies single-cell transcriptomics, epigenomics, lipidomics and/or proteomics (preferred) – or – in functional genomics (e.g., siRNA, shRNA, CRISPR/Cas9) screens (preferred).
- Strong research experience in establishing, modifying, and optimizing techniques related to the areas of neuroscience, inflammation, and disordered proteins.
- Expertise in high throughput imaging techniques including but not limited to confocal, electron microscopy, FRAP, 2P imaging.
- Strong research experience in small animal surgery, AAV methods, etc., is highly preferred.
- Knowledge of experimental design.
- Statistical and quantitative analysis skills.
- Basic bioinformatics skills (preferred).
- Self-motivated and highly dedicated.
- Effective organizational and prioritization skills.
- Strong writing skills evident in published work and efficient grantsmanship skills.
- Effective oral, written, and interpersonal communication skills.
- Ability to work both independently and collaboratively in a multidisciplinary environment.