Jobs
Development and Optimization of Methods to Diagnose Alzheimer´s Disease Using Blood Tests
Posted 11 Oct 2023
Employer
University of Gothenburg
Location
Gothenburg, Sweden
Principal Investigator
Principal Investigator
Laia Montoliu-Gaya
Contact
laia.montoliu.gaya@gu.se and henrik.zetterberg@clinchem.gu.se
Description
Approximately 55.2 million individuals worldwide grapple with dementia, a number projected to increase exponentially in the coming years. Among the various forms of dementia, Alzheimer's disease stands out as the most prevalent, accounting for 60–70 percent of the total cases. Diagnosis of Alzheimer's disease traditionally has been based on clinical criteria, and nowadays, it is greatly aided by both cerebrospinal fluid (CSF) and positron emission tomography (PET) biomarkers. Although highly accurate, the broad implementation of these biomarkers is restricted by high cost, limited accessibility, and invasiveness. In recent years, advancements in technology, with improved sensitivity, have paved the way for the development of assays targeting brain-related proteins in blood. These assays have proven to be reliable tools for Alzheimer's disease diagnosis. The focus of this Ph.D. project is to develop and optimize methods (utilizing Mass Spectrometry and immunoassays) for quantifying Alzheimer's disease biomarkers in blood. Additionally, the project will investigate how blood proteins can impact the accuracy of Alzheimer's disease tests and explore simpler systems for sample collection and biomarker measurement. This Ph.D. position will be based at Gothenburg University in the laboratory of Kaj Blennow and Henrik Zetterberg. This research group offers an ideal environment for etiopathogenetic and translational research in Alzheimer's and other brain diseases, boasting a team of both medical doctors and biochemists. The laboratory is well-equipped, featuring a wide range of instruments for protein chemistry, proteomics, and immunoassays. Collaboration is a key aspect of the work, and the group partners with various academic research groups, both nationally and internationally, as well as industrial partners.
Requirements
The laboratory is seeking a Ph.D. candidate with a strong foundation in biochemistry and, preferably, prior experience utilizing immunoassays and high-resolution LC-MS/MS mass spectrometry. Proficiency in data analysis and advanced statistical skills will be highly advantageous. The role demands effective interpersonal and communication abilities, meticulous and methodical work habits, and a keen interest in Alzheimer's disease research. Creativity, a cooperative spirit, initiative, and the ability to work collaboratively in a team are essential. The successful candidate should possess critical thinking skills, excel in presentations and written communication, and demonstrate a strong commitment and positive attitude. He or she should be capable of working both within an interdisciplinary team and independently, aligning with the project's defined objectives. Further specifications about eligibility criteria and the application process can be found in the following link: https://web103.reachmee.com/ext/I005/1035/job?site=7&lang=UK&validator=9....