The center holds a unique archive of brains donated by individuals with neurodegenerative disease and neurologically normal controls. It specializes in parkinsonian movement disorders, including Parkinson’s disease and multiple system atrophy and holds the national collection of brains donated by individuals with progressive supranuclear palsy (PSP). Recently the collection has been developed to include donated brains from prospectively studied people with familial dementias. Brain tissue is stored as formalin-fixed, wax embedded blocks and is frozen, either at –20 °C or at –80 °C (flash-frozen). Tissue can be provided to researchers as slide-mounted sections, or as small blocks for neurochemistry, proteomics and DNA and RNA analysis.